RAF Typhoon jets have operated alongside French aircraft in a joint strike targeting an underground arms cache in Syria employed by the IS group, as stated by the British defence ministry.
The location, identified by intelligence, was thought to be containing munitions and bombs, the release indicated, and was situated in mountains just north of the ancient city of Palmyra in the heart of Syria.
"Our aircraft employed precision-guided Paveway IV munitions to target a number of access tunnels providing entry to the site... early reports indicate the objective was successfully hit," the ministry announced.
There was no sign of any harm to civilians in the strike on Saturday evening and every plane involved made a safe return, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
The Islamic State group - also known as the so-called Islamic State - imposed militant control over large swathes of Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates British leadership, and resolve to stand shoulder to shoulder with our allies, to stamp out any revival of Daesh and their dangerous and violent ideologies in the area," UK Defence Secretary the Defence Secretary stated.
UK warplanes have conducted patrols over Syrian airspace to "forestall any efforts to regroup" of Islamic State following its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I want to thank every member of our armed forces who took part in this strike for their skill and their valour," he said. "They were among thousands of British troops stationed over Christmas and New Year. This action, to remove militants who threaten our way of life, highlights how UK forces are always on standby, all year round, keeping Britain secure within its borders and powerful internationally."
Last December, the US military carried out what it called a "massive strike" targeting Islamic State objectives in the country, subsequent to an ambush killed two US servicemembers and a civilian linguist in the Palmyra area.
The U.N. says IS still maintains between 5,000 and 7,000 combatants in Syria and Iraq.